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Early Phase 1RecruitingNCT06338553

GLP-1RA added around teplizumab in stage-2 T1D

What this study tests

Vanderbilt pilot crossover study of single-dose oral semaglutide (Rybelsus) versus placebo during MMTTs, mainly in stage 2 T1D around clinical teplizumab treatment, with a separate early-stage-3 GLP-1Ra monotherapy aim.

Editorial review: .

Registry checked: 2026-09-17. Registry’s own update: 2025-12-18.

Source dates appear in the references where available; this record has no dated citation metadata.

Trial status, labels and access can change between reviews. How we review the evidence · How to read the evidence

Full sources ↓Full discussion ↓Report an issue →

Evidence at a glance

Who can enter the study?
People aged 12-50 with early-stage T1D receiving teplizumab. Registered eligibility ↗Enrollment criteria describe who may enter. They do not establish who was analyzed or the denominator for a reported result.
Reported benefit and results
No results posted yet.Read the result sources and their limitations →
Important harms
Read the reported results, safety discussion and original sources. A separate harms summary is not available; this does not establish safety.
Research access and approval
Study regions: United States. A trial listing does not establish product approval or current recruitment at a particular site. Check the study’s current entry requirements.
What remains uncertain?
Read the full discussion and original sources for study limitations. Planned endpoints and completion dates are not results.

Research status alone does not establish approval, clinical benefit or local availability.

Primary endpoints

  • Impact of single-dose GLP-1Ra versus placebo on postprandial glycemia during MMTTs (pilot)
  • Impact of single-dose GLP-1Ra versus placebo on disposition index during MMTTs (pilot)
  • Impact of single-dose GLP-1Ra versus placebo on endothelial function (flow-mediated vasodilation) during MMTTs (pilot)

The full picture

This record has no longer discussion. Use the study criteria, reported results and original sources on this page to assess what is known and what remains unresolved.

Sources

  1. [1]